Pick a really boring, antiquated industry. Think about how you can add glamour to said industry. Think about how you can redefine workflow, transactions, purchasing, sales, marketing, etc. Change the way business processes run. If the industry dictates everything, try and build something that gives the consumer greater power/choices.
Thanks, this resonates greatly with how I would like to tackle things, while I guess your advice falls under industry disruption, I think I like it more simply because it challenges status quo and that is me through and through.