I think the correct reaction to depression is simply out of the question for too many people: drop everything, get the fuck out. Move somewhere you've always wanted to go. Find an interesting job. New friends. Trouble with a family member? Don't talk to them.

It's a clear step to break your environment from you that I highly recommend. It requires money, time, and the ability to realize just how destructive relationships can be. Most people can't/won't do it.