We did accidentally torch the Apollo 1 crew in their capsule.
My fav Apollo-era fuckup is when they tested the launch abort system. The test went bad, but was 100% successful in demonstrating it worked. Heh. https://www.youtube.com/shorts/DpdKxv9WINY
Over on the nuclear side there was SL1, which AFAICT is probably the answer to the question "why doesn't the US Army have its own nuclear systems?" https://www.youtube.com/watch?v=qOt7xDKxmCM .
"Explode until you figure it out" served Falcon 9 well.
I'm inclined to see Constellation/SLS/Orion/etc. as at least as wasteful as the explosions, at least so far. Which one wins out will depend on the end results.
While "explode until you figure it out" worked well on the Falcon 9, it was a lot of taxpayer money to develop a rocket system primarily used to launch their own product at this point - not delivering on price-points they claimed
I might be a little bitter that NASA doesn't get that money instead.