I'm using Nod32 (or whatever Eset calls it these days) for more than a decade and it's mostly not noticeable. I can recommend it over Defender from performance point of view - since I noticed slowdowns on machines where Defender is used. It's hard to know which one protects better, didn't have any kind of "infection" since started using Nod.
Or you love those popups from 3rd party vendors?