I used to smoke in high school and college and it was great, no negative effects. Then I took maybe a half year break at 21. When I smoked again I would get super anxious and paranoid. To the point where I just needed to go lay in bed and wait it out. I thought I smoked too much or it was stronger than what I was used to. Took it a bit easier the next time. Same thing. I stuck to methylone, ketamine, methoxetamine, 2C-E, and a little LSD after that. I was fine with all of those. Then one night I'm hanging out with some people I barely know, I had a little methylone and ketamine in me, took a puff or 2 of weed. Full blown psychosis for the next 12+ hours. I was convinced they were cops and I locked myself in the bathroom all night. I didn't touch weed or much of anything for a couple years after that. Fast forward to 2013, I'm living in Tacoma, weed was just legalized, I take a hit and I'm good, take another one and full blown anxiety attack and paranoia. Ok maybe edibles are ok, so I ate some edibles a few months later, not so bad, pretty chill. Over the years since then I've tried smoking, vaping, and eating THC and it usually leads to paranoia and anxiety. Not always though, it's like I'm just really sensitive to it and it's really easy to overdo it. I've found that the newer edibles that are from hemp extract and are only like 5mg THC are excellent. I drink a seltzer and I'm just chill and having a good time. 2 seltzers and I can feel the anxiety start to come on, but I'm still good. This whole time I've just been trying to chase that feeling it used to give me in high school.
I spent several years in my early 20s as a daily smoker, but at some point in the last few years, I crossed some sort of line, and I seemingly can't smoke at all anymore without winding up anxious as hell. Ultimately this led to me just totally giving the stuff up, which isn't the worst outcome. I still miss certain aspects of it, but after consistently having bad experiences for a while, it seems that I'm just better off without it.
I don't really drink either, so my vices now are limited to vaping and a very occasional small dose of mushrooms.