If you want to kill Hollywood, you need to kill its revenue streams. In the case of TV, that would be advertising. The examples you've raised are off to a good start there. Once brands and marketers see that these folks can reach bigger and more dedicated audiences each week than a typical TV show can, dollars will be taken away from TV spend and placed on YouTube instead. It'll be a slow process, but we're already seeing some really big brands and companies placing big bets on YouTube, Facebook, etc. There are plenty of cases where spending on a YouTube star makes more sense than spending on a TV show (when reaching a targeted audience or youth demographics, say). That said, YouTube -- and its associated studios -- have a ways to go before theyr'e taking serious bucks away from TV network advertising.
As for the movie business, that one's a bit tougher to kill. The barriers to entry for Hollywood-quality movies are fairly high. But there are some levers to pull. In recent years, hedge funds have quietly emerged as one of the biggest sources of film financing in the business -- bankrolling everyone from production companies to studios themselves. Independent producers looking to work outside the Hollywood system should find a) distribution paths that make sense, and b) court this sort of money, which will be agnostic as to who's making the content if the content is good enough.
As for the movie business, that one's a bit tougher to kill. The barriers to entry for Hollywood-quality movies are fairly high. But there are some levers to pull. In recent years, hedge funds have quietly emerged as one of the biggest sources of film financing in the business -- bankrolling everyone from production companies to studios themselves. Independent producers looking to work outside the Hollywood system should find a) distribution paths that make sense, and b) court this sort of money, which will be agnostic as to who's making the content if the content is good enough.