Yes. There are a couple point defense systems originally designed to counter rocket and cruise missile attacks that can readily attack drones as well. Example: https://www.youtube.com/watch?v=pb5_F4_Eod8 This specific system uses a magnetic coil to measure the muzzle velocity of the shell as it's leaving the barrel, and sets a timing delay for the shell to burst. So that combined with the radar means this thing can put flack in very precise places.
Drones, especially repurposed commercial drones are extremely fragile. Almost anything will work. It's the getting close to it that matters - with what? Another drone?
