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"Look at the early Covid pandemic and the shortage of face masks and other protective equipment. Look at vaccine production and how countries that could manufacture the vaccine prioritized domestic distribution first."

I don't think those are very good examples. A large part of the PPE shortage problem was from not restocking the national stockpile after the 2009 swine flu pandemic, in part from a bi-partisan, multiple administrations by both parties capture of that program by Emergent BioSolutions.

Which then abjectly failed when it had to deliver cell culture grown vaccines in its Baltimore plant that was in reserve for pandemics (fortunately that didn't hurt so much because the Janssen and Oxford vaccines are ... subpar, and Protein Sciences approach which works for flu generally failed or were extremity late (Novovax and Sanofi Pasteur)). We had part of a system and failed to use it properly. On the other hand if we as in the US were sharp we'd have bought the equipment Honeywell ended up scrapping when they shut down mask making in France.

3M for example does make masks in countries like the US and even keeps an extra set of equipment to double production in case of emergencies like this. But of course just doubling normal production isn't enough, and they and other companies like some that got crushed after 2009-10 found it hard to compete against very cheap PPE from the PRC, and refused to risk their companies again after COVID started hitting.

For vaccine manufacturing it's a tall order to expect political systems to be ready for once in a century events. This wasn't so bad for us with COVID since we could tool up during the development and testing of vaccines although the Indian national government abjectly failed to do that, but there was always going to be issues here, especially in learning curve issues.

Also how do you prepare for the best vaccines being mostly completely new technology for mass manufacturing? Even for fill and finish BoNTech's vaccine has at least at some point temperature requirements way beyond normal medical freezing, the latter any of us could achieve with a frost free consumer freezer.

In general, though, you're right, but solutions free of their own corruption problems are very hard. Plus tariffs are regressive taxes.



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