Unmarried, childless, 20-something me would have loved nothing more than to have that kind of isolation. I love my family, but I could very easily picture myself not interacting directly with people and being very happy.
I thought I'd be cool with it too, and for the first few months I was. I'd occasionally meet up with friends, but in general would go weeks and not see much of anyone. However after a while this situation started taking a fairly significant toll, and I started making a point of arranging something with someone every weekend, just to get some non-video-chat interaction.