For me main use case is reading research articles annotate on it and sync it with my desktop and share it with my colleagues. Ideally I wanted a bibliography library tool like mendeley or zotero and keep all my annotations and notes synced. But that is far from possible on any e-ink tablet so far I have tried.
You can get reasonably close. You can use the zutilo extension for zotero which offers you a "move to tablet" option where you just point it to directory. I point it to a fuse mount of the remarkable. When zutilo moves the pdf to the tablet it removes it from the bibliography (just the pdf) and adds a special tag. At a later point you can do a fetch from tablet and zotero pulls back the paper from the tablet directory and extracts the annotations. This is also the biggest issue, because it can't extract text from your handwriting.