The reality is that vaccines target multiple proteins and one protein mutation usually does not even evade that specific protein from matching (much).

It's a sliding bumpy scale with each mutation reducing the effectiveness of the vaccine some small random amount.

It's very likely that all the current vaccines confer sufficient immunity to all current variants to a degree that will prevent serious Illness and likely even transmissibility.

But the real takeaway here is that, like flu, we are looking at yearly covid boosters for everyone for years to come.