Yes and no. Antibodies bind against essentially anything on the virus surface, and (depending on the exact type of antibody) do that to multiple virus particles. This is often enough to prevent the membrane from successfully merging with a cell and therefore prevents or seriously reduces the infection rate (you don't have to get infection rate to zero, just low enough). Additionally these antibodies are collected and expelled by other parts of the immune system.
But afaik the immune system does nothing to target active sites. This makes sense: specificity matters. For example disabling HIV is easy: just prevent CD4 binding. That will prevent the virus from attacking any human cell. Unfortunately, it has the same effect as AIDS, over time it cripples the immune system. You want to bind, not to the active sites, but to whatever is on the virus and isn't on anything else.
But afaik the immune system does nothing to target active sites. This makes sense: specificity matters. For example disabling HIV is easy: just prevent CD4 binding. That will prevent the virus from attacking any human cell. Unfortunately, it has the same effect as AIDS, over time it cripples the immune system. You want to bind, not to the active sites, but to whatever is on the virus and isn't on anything else.