Yes, pretty much since most ISPs do not block UDP port 53.

I have no reason to run DNS on a home internet connection. What would a sane use case be? They don’t block it because it would be stupid to use it anyway.

Ports that are typically blocked include 67, 139, 161, 520, 547, etc.. ie dhcp, rip, smb, snmp... none of them are any great loss to those that want to run a vpn.

Running a VPN or ssh service is another story and it works fine both TCP and UDP.

As someone else pointed out, the issue is mainly NAT not necessarily just "blocked" ports. What works with your ISP may not work with someone else's.