> Unfortunately, the MHC proteins are themselves a highly reactive antigen thahttps://www.airships.net/hindenburg/interiors/t triggers the immune system. Luckily, the body learns during a process called "negative selection" to cull any immune cell receptors that recognize your own MHCs:
This is very interesting that this process is split into two separate domains / privilege levels. That way you can't have a fork bomb that would overwhelm the MHC production process.
> Unfortunately, your body doesn't know the shape of MHC proteins from donor tissue and can't learn to kill any TCRs that match.
Maybe we'll combat this in the future by finding a way to donate or genetically engineer a whole bone from the organ donor, thus having bone marrow matching the donated organ. If we could get localized immune suppression on only those parts, that would be cool. I guess those leukocytes would be attacked immediately.
> Unfortunately, the MHC proteins are themselves a highly reactive antigen thahttps://www.airships.net/hindenburg/interiors/t triggers the immune system. Luckily, the body learns during a process called "negative selection" to cull any immune cell receptors that recognize your own MHCs:
This is very interesting that this process is split into two separate domains / privilege levels. That way you can't have a fork bomb that would overwhelm the MHC production process.
> Unfortunately, your body doesn't know the shape of MHC proteins from donor tissue and can't learn to kill any TCRs that match.
Maybe we'll combat this in the future by finding a way to donate or genetically engineer a whole bone from the organ donor, thus having bone marrow matching the donated organ. If we could get localized immune suppression on only those parts, that would be cool. I guess those leukocytes would be attacked immediately.
> https://en.wikipedia.org/wiki/V(D)J_recombination
Wow.