Don't you think that's a bit of a strawman? The user is explaining how that number is pronounced in their native Swiss French. Clearly nobody is suggesting you have to learn French to say some numbers.
I think this might be the disconnect between us. From my point of view as a non-native English speaker, the approach proposed in the tweet and that Swiss French system both requires the user to learn a new system. To me, both of that carry more drawbacks than just reading the hex character by character, in a group of 4.
I can give an example using the system in the tweet:
2F3E: twenty frost thirty ernest -- longer to read, 7 sounds.
2F3E: 2, F, 3, E -- shorter to read, 4 sounds.
Looking at that, I don't see the benefits and trade offs of that new complexity, and that's why I asked for help :)
Two Zero Zero One Colon Delta Bravo Eight Colon Eight Five Alpha Three Colon (pause) Colon Eight Alpha Two Echo Colon Three Seven Zero Colon Seven Three Three Four.
The part in the middle might need a better way of announcing, but given the double digits in other parts of the address it seems more natural to read it as a string of characters than to alter it.