Sorry for the late response--I just now saw this. We've fixed thousands of screens at this point--we'd have an angry mob if screen replacements caused the issue!
Yes, we have had people come back with Error 53; that's how we knew it existed a while ago. All of them had either had their home button replaced or water damaged. We were able to successfully recover one of them after the Apple Store told the guy there was nothing they could do. It was a water damaged home button and we were able to clean the corrosion off of it by soaking it overnight in a special solution. It came back the next day. If your original home button stops working, though, you are screwed.
Yes, we have had people come back with Error 53; that's how we knew it existed a while ago. All of them had either had their home button replaced or water damaged. We were able to successfully recover one of them after the Apple Store told the guy there was nothing they could do. It was a water damaged home button and we were able to clean the corrosion off of it by soaking it overnight in a special solution. It came back the next day. If your original home button stops working, though, you are screwed.