There's two issues, success rate (about 5%) and time ... even if it is successful in humans, it will be 5 to 10 years before it's available (and 20-30 before it's affordable)

This is not being a contrarian, but a realist.

To be fair, this same realist perspective seems to suggest humans would not have been capable of developing a COVID vaccine for 5 to 10 years; yet, they identified the virus and authorized vaccine use within eight months.

Not to diminish the accomplishment of rolling out the Covid vaccine in such a rapid timeframe, but… there was something like 40+ years of research into creating mRNA vaccines that laid the ground work.

They have a PDF in the downloads, and an epub one if you have an ebook reader like a kindle or kobo

Porque no los dos?

He was a super-rich guy, who had had too many people telling him he was a genius for way too long (reminds you of anybody?), and so was way too sure of himself. A bunch of his ideas were crazy, which doesn't mean others weren't trying to dismiss his views.

> A bunch of his ideas were crazy

Which ones?

btw young idealistic me voted for Perot in 1992

All shoe sizes should only be small, medium, and large. He really did have a lot of very ridiculous ideas. He also had a lot of extremely good ideas and incredible understanding of socioeconomic conditions.

His book “United We Stand” with modern context is quite amazing considering it came out in the early 90s.

I too would like to know.

This is one research paper reporting on particular results.

It is DEFINITELY not too early to tell. Cervical cancer rates in Australia, which adopted the vaccine widely and early have decreased, and it has been widely reported ( https://www.canceraustralia.gov.au/cancer-types/cervical-can... )

There's nothing particularly bad for adult males.

The benefits may be statistically lower, since you may have been infected by some of the variants already, older males may have fewer sexual partners in the future, and cancer takes a while to develop.

In the USA, it is recommended by default for adults up to 26 and kinda for 27-45.

That would be up to individuals or health departments, who decide what risk is high enough. The risk for non-promiscuous people in 'western' countries is so low, that I don't see any country giving this to everybody.

This is not a vaccine, BTW, and it needs to be given every 6 months.

This heavily heavily depends on the population you choose, given the difference in sexual habits.

As a data point, the paper below shows 1,213 out of 18,401 high-risk people in France got infected in 4 years (and 260 out of 31,992 with the previous gen prep, it seems this one reduces it by ~10x again)

https://www.thelancet.com/journals/lanpub/article/PIIS2468-2...

Thanks for that! So yeah, by that, existing PrEP is very effective, and this new one is much better yet.

What a medical miracle, seriously!

It is some of both. Business conditions have changed, but also the bosses kinda collude to reduce power of the employees.

Eventually some companies will start scooping talent up, and everybody will zig :)

There's so many different people, and it's hard to know if that's made you lose customers.

I would immediately discard any website that makes me send an email to order.

Me too. I don't want to be signed up for some email spam, and I don't want to initiate a conversation about buying something if I don't already have enough information about it to want to buy it.

We do, it's not as if we aren't doing any testing. I've been getting a yearly prostatic antigen test for several years now.

The recommendations tend to take these into account, and then you and your doctor adjust.

Sometimes politics gets into it, like with the recent changes to breast cancer recommendations, but, overall, it works well for many people.