The most surprising effect of Mounjaro, at least initially was that it drastically reduced by desire to drink beer, and when I started, my drinking was at a very unhealthy level (beer calories being a major factor in my weight problem). But maybe I'm an odd case, as I had a real beer habit but don't like wine and very rarely touched spirits.
Actually losing some weight as well as cutting my drinking down, helped me with depression far more than SSRIs (which had previously led to even faster weight gain)
Unfortunately, the effects started to diminish somewhat after about a year on it, as if I was building up a bit of a tolerance to the drug. And then I switched to Wegovy (=Ozempic) after big UK price hikes to Mounjaro, and found it much less effective, started gaining weight again (winter/xmas didn't help). Switching back to Mounjaro at the moment, but having to slowly step back up from a lower dose. Not expecting to see the initial near-miraculous effects again, expecting to have to combine it with some actual willpower and more exercise going forwards.
The really beautiful thing now is that, with the evidence from GLP-1 drugs as a class, we're seeing 3 things: new targets for all kinds of things, that were previously discarded as "too difficult to make into medication", and in addition, injectable treatments - for a long, long time anything that required injections was just ruled out at the mechanism level. The third thing is that pharmaceutical industry has learned how to hit multiple targets with a single drug - previously most drugs were formulated to hit at most one or two receptors, and now we're seeing work on quad or 5-way drugs.
I'm super optimistic, the pipeline for future medications in these classes and other related ones are enormous. Huge effects both for me personally but for the world as a whole, a world in which obesity and other chronic behavioral conditions are treated more like cancer than smoking - even smoking itself!
I've had a similar experience where I'd be craving a beer, but not really craving alcohol since wine or spirits didn't sound appealing at all. I think it might actually be the hops and not the alcohol.
I don't know if it's common in the UK, but in the US, a lot of breweries have started making hop water. I've found that it can really scratch that itch. Even just a hop tea might work if you can't find pre-made hop water.
It sounds weird, but it's actually delicious with nice floral and citrus notes and just enough bitterness that you don't drink it too quickly.
It’s not just you. I’ve known several people who lost their desire to drink beer specifically on these drugs. I didn’t personally experience it, but then I am more of a whiskey guy.
Mounjaro is widely known to cause bad hangovers and side effects while drinking isn't it? That's what I gleaned from my research. I'm a little surprised you didn't come across that
Curious also if you're considering staying on the lowest dose for cost purposes? I've ignored all advice to step up from 2.5mg and I can even go 10-14 days without noticing too much, but weight loss is slow compared to others (12kg in 6 months). But that's how I want it to be honest.
Though I guess lower dose for longer might work out more expensive
Creating some sort of genetically-engineered dinosaur-derived ‘dragon’ may be more plausible than actually reaching another star system. It’s not going to breathe fire though.
We can’t render modern games at decent frame rates at 4k without going down the path of faking it with AI upscaling and frame generation.
There was no hope of actual 8k gaming any time soon even before the AI bubble wrecked the PC hardware market.
Attempting to render 33 million pixels per frame seems like utter madness, when 1080p is a mere 2 million, and Doom/Quake were great with just 64000. Lets have more frames instead?
(Such a huge pixel count for movies while stuck at a ‘cinematic’ 24fps, an extremely low temporal resolution, is even sillier)
Yeah, not only the huge required jump in raw fill rate, but to get the most out of a 4K TV you need higher detail models and textures and that means you also need a huge jump in VRAM, which never materialised.
I don't see a future in which we play at 4K at top settings either without AI upscaling/interpolation. Even if it were theoretically possible to do so, the performance budget the developers have going forward will be assuming that frame generation and upscaling is used.
So anyone who wants only "real frames" (Non upscaled, non generated) will need to lower their settings or only play games a few years old. But I think this will be something that becomes so natural that no one even thinks about it. Disabling it will belike someone lowering AA settings or whatever. Something only done by very niche players, like the CS community does today where some are playing 4:3 screens, lowering AA settings for maximum visibility not fidelity and so on.
Prusa may still be king if you're using printers commercially, running them hard 24/7 in a print farm, wanting to be sure your investment has a decent lifespan with readily-available spare parts and upgrade options.
But it's a premium brand now. For lighter use by hobbyists, Bambu is the clear winner on price/performance. The 'less open' downside is not a factor to most people, and the printers generally work so well out-of-the-box that repairability isn't as much of a concern as it was on printers of the past.
Personally I went from a Prusa MK3s to a Bambu P1P (after looking long+hard at Prusa options), and so far, no regrets. (Although I've kept the old Prusa as a 2nd printer and upgraded it to a MK3.5, but mostly just because I do enjoy a bit of tinkering with them)
If your goal is to buy the cheapest machine you can find in the world, chances are good everything you buy is going to come from China. That Prusa Mk3 you bought ages ago can be upgraded to the latest model, which means you have the option of turning that device into a lifetime machine, something ONLY Prusa offers.
Yes, the initial purchase price is higher, the lifetime price might not be.
Last time I looked, the MK3->MK4 upgrade kit is basically the same price as a complete MK4 kit (very little can be reused. New electronics, motors, extruder)
The upgrade kits are definitely a good thing, going from MK3 to MK3S to MK3.5S was a worthwhile upgrade path and has prolonged the useful life of the printer. But they have their limits.
(And with 3D printing going more mainstream, there's a large segment of the market that has no interest in building printers from kits or stripping down printer to install upgrades - even though some of us find that quite enjoyable)
They don’t provide a large platform for political speech.
This isn’t about AI or CSAM (Have we seen any other AI companies raided by governments for enabling creation of deepfakes, dangerous misinformation, illegal images, or for flagrant industrial-scale copyright infringement?)
No because most of those things aren't illegal and most of those companies have guard rails and because a prosecution requires a much higher standard of evidence than internet shitposting, and only X was stupid enough to make their illegal activity obvious.
That could be used to justify banning drones in general, or banning all drones which aren't radio controlled (not that those are being used domestically). And "it can be used for war" is a bit silly in a country where you can buy guns at the grocery store. Not to mention that cars can be very effective weapons as well, and those haven't been banned yet.
The far more likely explanation is that they just don't want people filming them. They can't legally stop someone with a cellphone from filming them, but that hasn't stopped them from using up-to-lethal force against observers. On the other hand, you can't exactly beat a flying drone into submission, so the obvious move is to observe using drones instead.
Luckily for ICE the FAA already has the mechanics in place to criminalize flying drones in certain places, so with their magic "no drones anywhere we operate" NOTAM they can now punish observers with a year of jail time.
I agree with your point but they definitely want to kill you for being in a car and driving near them if they get scared so IDK if we can use cars as an example of something they don't mind
There’s a finite (albeit vast) amount of content to serve up.
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