If it is a little bigger to incorporate a bigger chip antenna and some GPIO pins, it is going to be very useful for a lot of IoT projects!!

The XIAO series of ESP32s is exactly that.

They are 4x the size though, almost exactly double in both length and width.

https://wiki.seeedstudio.com/XIAO_ESP32C3_Getting_Started/

It's also got 15 times as many GPIO pins as the board in the fine article.

And this PCBA will be smaller than the battery in most applications anyway.

It only has 14 pins, 3 of which are 5v, 3.3v, and ground, so slight exaggeration :-) point taken though

These are nifty. I've used them in production, but if you want to make used of the charger it's difficult.

These are quite lovely. Ceramic SMD antennas are awesome.

Definitely would be more functional with more of the GPIOs exposed.

If you want an ESP32 dev board with GPIOs exposed there are dozens (or hundreds, maybe thousands) of other options out there. It makes sense not to expose them when you're going for the smallest possible footprint.

I don't know, I see enough space for four GPIOs there. Not holes, obviously, but pads should be very workable.

It could be even smaller without that USB C port and have more GPIO pads.

there is plenty of those already and not all too hard to make yourself, see LilyGo T01-C3

Its of format of original ESP8 so you get serial + 3 IO pins

Can anyone suggest a small module that supports 5 GHz WiFi?

Couldn't we get a low-res version of this info by tracking the active window using a cli tool? For linux, there are several options. Not sure about Mac.

Another approach is to run OCR on 1FPS screenshots. Everything runs locally without draining the battery like an LLM would.

You definitely could! I think it would just be harder to get good semantic understanding of what you did during a segment of time without LLMs.

Off topic, but I assume the name braintrust comes from Creativity, Inc. Amazing book by Pixar co-founder Edwin Catmull.

Relevant XKCD - https://xkcd.com/86/

I had a similar experience.

It did not change the text on a hat (ended up changing 1 of 3 words).

On one occasion it regenerated the same image again, ignoring my instructions to edit.

I get the feeling that this model is optimised for images with people in it than objects or drawings etc

> from idea to solid working product

What platforms have you been using for this? Did you face any challenges in getting the backend setup?

How are the RNA sequences used? Are there any clinical trials running?

There is a number of different technologies. Some of the big ones are:

- mRNA therapies: These therapies deliver a synthetically created messenger RNA (mRNA) molecule, typically protected within a lipid nanoparticle (LNP), to a patient's cells. The cell's own machinery then uses this mRNA as a temporary blueprint to produce a specific protein.

The big example here is CAR-T therapy from Capstan which just got acquired for 2.1B. Their asset,CPTX2309 , is currently in Phase 1. Previously to do Car-T therapy you had to extract a patient's T-cells and genetically engineer them in a special facility. Now the mRNA gets delivered directly to the patient's t cells which significantly lowers the cost and technical hurdles.

- RNA interferences (RNAi): Used for gene expression knockdown through natural cellular mechanisms for viral detection. The big example here is Alnylam with 5 approved therapies and a number in clinical trials.

- Antisense Oligonucleotides (ASOs): Short single stranded RNA molecules that get delivered directly to the cell and target an existing mRNA. The big win here is Spinraza which is the first approved treatment for Spinal Muscular Atrophy (SMA) which previously didn't have a treatment. The Spinraza clinical trial (ENDEAR) was so effective that they deemed it unethical to continue it because the control arm wasn't receiving the treatment. Prior to Spinraza most patients would pass away prior to two years of age.

What is this?

This is quite similar to what I was trying to explore with [1] & [2] yesterday. Currently, the only option I found is to use localStorage and give the user the option to manually export and import.

Hyperclay has given me some ideas. What I want is something like [3] but that the user only needs to install once. One electron app that can load our mini-apps.

[1] - https://news.ycombinator.com/item?id=44930814

[2] - https://news.ycombinator.com/item?id=44933897

[3] - https://www.electronjs.org/fiddle

I had the same problem, regarding localStorage synchronization. For that I made htmlsync.io, but only really worth it for people who have many local apps like that and really need the localStorage sync.

This is pretty cool! What kind of users are you targeting? Technical folks or those dipping their toes into dev with vibe coding?

Thanks! Pretty much, yes. Also if you are a dev and just don't want to spin up a server for every simple app you vibe code, you could find this useful.

To be honest, I wanted this for myself and felt guilty not making something more serious out of it since I liked the idea.

This thought is what triggered me to try and build an offline web app - https://news.ycombinator.com/item?id=44930814

After building this, I realise that we need a standalone electron that can download and run offline apps that are more complex.