Yes, there is no question about that the uBlock Origin works regardless of your YouTube session status. The question is whether YouTube's countermeasures kick in or not: nagging you to turn it off, or stop playback.
Yeah, that's what I have been wondering all the time, people claiming that Adblockers stopped working, now people are developing new extensions/blockers, but here I am, playing YouTube without ads like before, with nothing more than uBlock Origin....
It gave me the warning with uBlock origin a few weeks ago. I think the ad-detection is not turned on for all, that's why it may seem it still works. It also could be that some of the filters in uBlock trigger the detection more than others.
I see no reason why it shouldn't. Most of homebrew is ruby script (that is architecture-agnostic), most of software installed through homebrew can be recompiled.