I'm all for laxer regulation of substance control e.g. buying cocaine at the grocery store, but I think its also a bit misleading to describe arbitrary sequences of amino acids as if they're meaningfully comparable to food.
That's like saying that since neither one nor zero requires regulation, neither does software. Maybe software does or doesn't, but in either case its best based on the nature of the aggregate, not the nature of its components.
I imagine it's legally risky to buy a large quantity, test it, and then resell smaller quantities. That's a shame because the alternative is probably that some folks settle for products of dubious quality and end up getting hurt.
Yes, I believe most people buy directly from somewhat shady Chinese factories. I tried contacting a few and they all refuse to meet or send samples from within China, so I assume what they're doing is illegal in China. In the US, it's legal to sell them as a "research chemical" but the FDA is cracking down on companies that are clearly engaging in b2c.
Right, but I don't know the people at those companies. I have local chemists that I trust. I'm just lamenting the fact that developing that kind of trust network everywhere, so everybody can be similarly sure of what they're putting in their body, is likely to run afoul of local laws.
FWIW, finnrick's claim to fame is being free. Someone is paying for it. They have also failed blind tests in the past, Janoshik (IIRC) never has. There are several US-based labs but none of them have the same reputation as Janoshik.
Actually, you just described most of the tele-health and compounding pharmacies that carry GLP1s!
Where do you think Hims, Ro, Brello, or the rest get the APIs they sell to their customers? They get them from grey market suppliers in China. They don't go to Ely Lilly or NovoNordisk and say, "politely sir, may I skirt around your IP and sell your drugs for 10x what they cost instead of 10,000x what they cost?" Hopefully, they test them and filter them and use sterile/pharma processes for what they sell to their customers. Well, except for the Medspas, those are just wild west snake oil farms.
Things have changed a little, but during the time that compounding was explicitly allowed, the licensed pharmacies were buying from FDA approved manufacturers, sometimes in China, and sometimes the same manufacturers who also do contract manufacturing for Lilly.
Today ... who knows? It might just be the same gray market stuff us plebes can get.
It probably is, but that does not stop people from effectively doing it. There are a number of groups that specialize in conducting group buys, doing a bunch of testing on randomized samples, and then shipping out the product to individuals.
Also, if you plan to be on it a good long time, you can buy a bunch of kits yourself (a kit is 10 vials), run a bunch of tests, and then just have a nice stockpile that will last you years. The testing will likely cost as much or more than the product itself, but given how inexpensive the product is, you still come out way ahead financially.
>I imagine it's legally risky to buy a large quantity, test it, and then resell smaller quantities
It is illegal, but it doesn't stop people from doing it. In fact, if you don't have any sort of test results for your peptides people will absolutely avoid buying your wares until you have them. Purity and mg/ml are the 2 basic test results that any shop worth their stuff will have.
To be fair, most everyone I know who is buying on the gray market considers vendor tests to be minimally required, but still insufficient -- there is no assurance they tested the product they shipped to you. Plan on testing it yourself. I'm sure some people do trust nexaph enough, though, to not worry so much. Whether that trust is well placed, that is a separate discussion.
With most of these you can really tell if they work or not and there is a pretty predicable dose dependent reaction profile. With slow meds like semaglutide you'd maybe not notice it in the first week but you will by week 3. I had mine tested but if that wasn't available I probably would have considered the anecdotal evidence to be sufficient. It appears that most of the scamming is just people taking the money and not shipping anything.
The most dangerous failures I've seen have been sending the wrong peptide. 15 mg of tirzepatide and 15 mg of semaglutide is a very different experience.
After nearly getting hosed in a group buy (I did get refunded, but that is far from a guarantee) because of a product mismatch, I decided to just pay for nexaph. Love him or hate him, his popularity relies on his reputation and he has been more careful than most suppliers to cultivate it with more extensive testing and quality control.
That makes sense, I don't like that the bottles are unlabelled so the first thing I have to do is label them. The box is labelled and this seems to be standard practice. Semaglutide is falling out of favour so I guess they're substituting. I have 4 years supply now so I guess I'll check back then and see where the market is at.
I know a bunch of people with multi-year stockpiles. I've got ~5 years of reta and ~6 years of tirz. This is too much, of course, but I determined a while back that under no circumstances do I ever intend to find myself unable to source it. My life is immeasurably better after losing 110 pounds.
There is a genre of music that my old roommate was into which titled all of their songs and albums in obscure Unicode characters with no known pronunciation. Songs in this genre may not be perfect antimemes, but I think their resistance to reference is an antimemetic property.
Also, chromosomes are nucleotide-encoded memes, and linear ones use teleomeres to impose limits on the number of replications they support, so that's another imperfect antimeme.
I know of no antimemes whose antiemetic nature comes from their ability to interfere with the human mind, but then again, I wouldn't know about them if they existed, which is more or less the book's point.
A malicious antimeme would be a dark pattern in web design for handling privacy/data/etc. Something designed to satisfy whatever law/regulation requires them to have the option while making the ability to find/remember/interact with it as hard as possible.
Another candidate is the common usage of memory-holing, where important information is removed from public perception maliciously. The Dubai Chocolate thing technically falls into here, as does the whole "war in Iran to distract from the Epstein files" thing. Frankly the whole Epstein stuff is riddled with malicious memes and antimemes to deliberately muddy the waters. Similar to deliberate attempts to inject insane conspiracy beliefs "the moon controls our brains" into conspiracy theories that are too close to something real "mk-ultra".
Consciousness for an antimeme is more of a classification error in my mind, as consciousness as a concept is permanently warped. But you could describe a secret society/dark family secret as a form of living antimeme, hiding some information and preventing it from being shared using a variety of means.
They're also pretty awful if you try to use them for safety purposes. Like... how blue can purple be before it's not purple anymore, idk. Last year it was very purple, but now the test is a year older, or is the product non-uniform and that's why it's different...
Basically, if you inject enough suspicion into any situation, colorimetric tests will eventually lead you to believe that you're in trouble. And then later if you bring the sample to somebody with access to real equipment it often turns out there was no trouble besides the sort you were looking for in the first place.
I honestly think we could save a lot of lives by just putting a gas chromatography machine in the library next to the 3d printers and training people to use it.
But aren't you still going to have to convince other people to let you do it with their money/data/hardware/etc? The understanding necessary to make that argument well is pretty deep and is unaffected by AI.
I've been having a lot of fun vibe coding little interactive data visualizations so when I present the feature to stakeholders they can fiddle with it and really understand how it relates to existing data. I saw the agent leave a comment regarding Cramer's rule and yeah its a bit unsettling that I forgot what that is and haven't bothered to look it up, but I can tell from the graphs that its doing the correct thing.
There's now a larger gap between me and the code, but the chasm between me and the stakeholders is getting smaller and so far that feels like an improvement.
Every AI/agentic thread on HN follows the same tension: builders want to build and solve problems. Code or task completion are implementation details to be done on the path to the actual prize: solving the problem. And then there are the coders, that have honed their mechanical skill of implementation and derive their intellectual fulfillment from that. The latter crowd has a rough time because much of it can be automated now, the former camp is happy because look at all the stuff that can now be built!
That all sounds fine if they're not the kind of naysayers that will just let the company collapse around them rather than risk putting one of their own ideas out there on the chopping block. All too often nothing is the worst thing we can do, and there are a lot of professional do-nothings out there.
Immense wealth or power should be difficult to hold on to. Until our policymakers understand that we'll have to occasionally resort to the Luigi method.
Perhaps buoyancy could be a decent substitute, at least for the solid waste part. I imagine being waist deep and flushing the entire bathroom after each training session. Maybe some kind of spatula/squeegee might assist with separation, coupled with a robotic spatula cleaner and sanitizer. There would be a monitor and cameras so you could calibrate your aim. What an odd workday that would be.
The goal here is neutral buoyancy when in gravity so that it behaves as though there were no gravity. Put a bag of water in water and it floats like the rest of the water, gravity or no.
So you’re strapping yourself into a material with the same density as poop and then pooping into it? How is that cleaner than pooping in a bag or over a vacuum?
Neutral buoyancy is achieved with very specific densities. You can either make the astronaut buoyant, or you can make the poop, but not both at the same time.
Do you need both? I assumed the astronaut has a handle or strap or something to fix their reference frame to the toilet. They can be only partially submerged.
Really? I find that on MacOS apps are very inconsistent about whether popping open a menu shows me hints for selecting items in that menu. Those same apps are consistent about it on Linux.
And then there's the bonkers window manager which can't move focus directionally (e.g. Super + left) and so you have to fall back to Cmd + tab tab tab tab but even then there's no consistency about whether you're switching between app instances or windows instances within the same app...
Display of shortcuts in menus is the responsibility of the app developer (especially in the case of use of foreign UI toolkits). If you don’t see them it’s because its dev dropped the ball and the Mac version is an afterthought.
I think its more about priorities. I expect touch related features to be a bit rough on Linux and I expect the same for keyboard focused things on Mac.
That's like saying that since neither one nor zero requires regulation, neither does software. Maybe software does or doesn't, but in either case its best based on the nature of the aggregate, not the nature of its components.
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